Mało researchu w temat z mojej strony, ale przewinęł mi się niedawno komentarz w stylu "pomijając jak zrobić *szczepionkę* jako taką, czy istnieje publiczna wiedza jak robić *mRNA*??"
https://twitter.com/ClaireBerlinski/status/1373607396849950723
Midway through the article it suddenly hit me--I'm amazed it eluded me thus far--that the reason I've not yet been able to find a coherent account of *exactly how* you make mRNA in a lab is that ... it's a secret. A trade secret.
Z możliwym follow-up https://twitter.com/marypmadigan/status/1373663476636389384
Before COVID I was researching this kind of study for a sci fi story I’m writing. The info about mRNA is out there - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2995060/#__sec1title
oraz https://twitter.com/DrJohnTurner/status/1373673999805386754
In principle yes - it’s a solid phase synthesis with protection/deprotection sequences. You would need a lot of kit to do it and building the experimental expertise would take time... It’s similar to the Merrifield peptide synthesis... https://en.wikipedia.org/wiki/Robert_Bruce_Merrifield